Blog
Understanding How Spravato Targets Depression
- June 21, 2024
-
NeuroMod Health
Recent Posts
1. Glutamate Modulation
Glutamate is a neurotransmitter in the brain that plays a key role in neuronal communication. It is involved in synaptic plasticity, which is the ability of synapses (connections between neurons) to strengthen or weaken over time. Dysregulation of glutamate signaling has been implicated in mood disorders, including depression.
2. NMDA Receptor Activation
3. Rapid Onset of Action
The unique aspect of Spravato is its rapid onset of action. Traditional antidepressants often take weeks to show therapeutic effects, but Spravato may work more quickly. This rapid onset has led to interest in its potential use for individuals with treatment-resistant depression who have not responded well to other antidepressant treatments.
4. Neuroplasticity and Synaptic Connections
5. Administration and Monitoring
Spravato is administered as a nasal spray, and it is typically taken under the supervision of a healthcare provider in a clinical setting. Patients are monitored for at least two hours after each dose due to potential side effects, including dissociation, sedation, and perceptual changes.
It’s important to note that while the exact mechanisms of Spravato’s antidepressant effects are not fully understood, ongoing research is being conducted to gain a deeper understanding of its actions in the brain. Additionally, individual responses to Spravato can vary, and its use is typically reserved for individuals with treatment-resistant depression who have not responded to other treatments. Patients considering Spravato should consult with their healthcare providers to discuss its potential benefits and risks based on their specific circumstances.
